Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Reactant | HCID 68431695 | HCID 68431695 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68432210 | HCID 68432210 | — |
Reaction Steps
A mixture of 5-(2-benzyloxy-4-bromo-6-fluorophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (1.0 g, 2.21 mmol), NaI (1.18 g, 7.87 mmol), CuI (91 mg, 0.48 mmol) and (1R,2R)—N,N′-dimethylcyclohexane-1,2-diamine (136 mg, 0.96 mmol) in dioxane (15.5 mL) is heated at 140° C. for 1.5 h in a microwave. The reaction mixture is filtered through Celite and washed with additional dioxane. It is then concentrated to a smaller volume and used directly in the next step: MS (M−H)−=461.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08252820B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-a9fef62ab19448b687e917cffefa6536 |
|---|
| Source note | uspto-grants-2012_08 |
|---|
