HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → Methanesulfonic acid 2-bromomethyl-5-methylphenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Methanesulfonic acid 2-hydroxymethyl-5-methylphenyl ester | HCID 86638980 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methanesulfonic acid 2-bromomethyl-5-methylphenyl ester | HCID 86638983 | — |
Reaction Steps
To a solution of methanesulfonic acid 2-hydroxymethyl-5-methylphenyl ester (864 mg, 4 mmol) in DCM (45 mL) is added CBr4 (2.0 g, 6 mmol) and PPh3 (1.57 g, 6 mmol). The mixture is stirred at RT for 6 h. The solvent is removed and the residue is purified to give the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252820B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-65b1e38750a7478f928d025ca4b99136 |
| Source note | uspto-grants-2012_08 |