Methanesulfonyl chloride → HCID 68432298, compound

Participants

Reaction Steps

To a solution of 5-[4-(2-amino-4-methylbenzyl)-2-benzyloxy-6-fluorophenyl]-2-benzyloxymethyl-1,1-dioxo-1,2,5-thiadiazolidin-3-one (240 mg, 0.42 mmol) in pyridine (5 mL) is added methanesulfonyl chloride (0.064 mL, 0.84 mmol) and the solution is stirred at RT for 2 h. The mixture is then diluted in EtOAc, and it is washed with 1N HCl, brine and water. The organic layer is dried with MgSO4, and concentrated. The residue is purified to give the title compound.

Provenance & Evidence