Water → HCID 68430928, compound

Participants

Reaction Steps

To a mixture of 2.6 g (16.7 mmol) of 2-fluoro-6-hydroxybenzoic acid and 6.90 g (50 mmol) of potassium carbonate in 15 mL DMF is slowly added 8.5 g (50 mmol) of benzyl bromide. The mixture is stirred at room temperature for 5 h. Another 1 g of benzyl bromide is added and the mixture is stirred at RT for 18 h. The mixture is poured into water and is extracted with ethyl acetate. The organic phase is washed (3×) with water and 1× with saturated NaCl. The solution is dried over sodium sulfate and the solvent removed under vacuum. The residual oil is purified by flash chromatography to give the product. This is used directly in the next step.

Provenance & Evidence