Triethylamine → HCID 68431066, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(6-benzyloxy-3-bromo-2-fluorophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (1.0 g, 2.4 mmol), 2,2-dimethylhept-6-enenitrile (493 mg, 3.6 mmol), Pd(OAc)2 (108 mg, 0.48 mmol), triethylamine (1.67 mL, 12 mmol) and 2-(di-t-butylphosphino)biphenyl (286 mg, 0.96 mmol) in acetonitrile (15 mL) is stirred in a microwave apparatus at 100° C. for 10 min. It is then filtered and the solvent is removed to give the title compound as a red liquid. The material is used in the next step without purification.

Provenance & Evidence