HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3-(Benzyloxy)-7-bromo-1-fluoronaphthalen-2-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide → 5-[8-Fluoro-6-hydroxy-7-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-naphthalen-2-yl]-2,2-dimethyl-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3-(Benzyloxy)-7-bromo-1-fluoronaphthalen-2-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide | HCID 68432209 | — |
| Reactant | HCID 178419117 | HCID 178419117 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Product | 5-[8-Fluoro-6-hydroxy-7-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-naphthalen-2-yl]-2,2-dimethyl-pentanoic acid | HCID 17747297 | — |
Reaction Steps
This compound is prepared from 5-(3-benzyloxy-7-bromo-1-fluoronaphthalen-2-yl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one and 2,2-dimethyl-pent-4-enoic acid-9-BBN similar to Example 8, Steps A and B, except in Step B, Pd(OH)2 is used to replace 10% Pd/C: Retention time=0.98 min (Method A); MS (M−H)−=423.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252820B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-b9b19871356046f698b7e273e404be8d |
| Source note | uspto-grants-2012_08 |