Water → HCID 68431616, compound

HRID 889268Notes

Reaction equation

HRID 889268 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([NH:15]C(=O)C)=[C:13]([F:19])[C:12]([F:20])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].O>C(O)C>[CH2:1]([O:8][C:9]1[C:14]([NH2:15])=[C:13]([F:19])[C:12]([F:20])=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 68430800HCID 68430800, compound

Product 1

HCID 68431616HCID 68431616, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A round bottom flask containing N-(6-benzyloxy-2,3-difluorophenyl)-acetamide (1.0 g), potassium hydroxide (1.0 g), water (2 mL) and ethanol (10 mL) are heated at 90° C. for 10 h. The mixture is then concentrated and extracted twice with EtOAc and water. The combined organic layers are dried over MgSO4, filtered and concentrated. The product is used directly in the next step.

Workup

  1. concentrationThe mixture is then concentrated
  2. extractionextracted twice with EtOAc and water
  3. dry with materialThe combined organic layers are dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-62fbac95ca4e41beb5ef4b613de693a7
Source dataset
uspto-grants-2012_08
Patent number
US08252820B2

Reaction notes

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