Boron tribromide → HCID 17747408, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(3,6-bis-benzyloxy-7-bromo-1-fluoronaphthalen-2-yl)-1,1-dioxo-[1,2,5]thiadiazolidin-3-one (232 mg, 0.406 mmol) in CH2Cl2 (3 mL) at 0° C. under nitrogen is added BBr3 (0.731 mL, 0.731 mmol). The reaction is stirred at 0° C. for 5 min then the mixture is quenched with 1N HCl (50 mL) and is extracted 3 times with EtOAc, dried over Na2SO4 and washed with brine. The organic layer is concentrated under reduced pressure and purified on reverse phase HPLC using a gradient of 10-20% MeCN/water (0.1% TFA).

Provenance & Evidence