HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide diethylacetal → 3-(Dimethylamino)-2-(2-methylpyridin-3-yl)-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide diethylacetal | HCID 70913 | — |
| Reactant | Ethyl 2-(2-methylpyridin-3-yl)acetate | HCID 15169545 | — |
| Product | 3-(Dimethylamino)-2-(2-methylpyridin-3-yl)-acrylic acid ethyl ester | HCID 68704722 | — |
Reaction Steps
600 mg (3.35 mmol) of the compound from Example 39A are heated in 1.7 ml (10.0 mmol) dimethylformamide diethyl acetal overnight at 100° C. After cooling, the mixture is concentrated and the residue is purified by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252817B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-c7874aaac0c1419e922b6b0c11a6cdf2 |
| Source note | uspto-grants-2012_08 |