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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 889345Generated: October 30, 2026

6-chloro-N-(4-methoxyphenyl)pyridine-3-carboxamide → 6-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(4-methoxyphenyl)nicotinamide

https://huagongshe.com/reaction/889345

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-chloro-N-(4-methoxyphenyl)pyridine-3-carboxamideHCID 1483269—
ReactantN-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamideHCID 21914577—
Product6-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(4-methoxyphenyl)nicotinamideHCID 21914591—

Reaction Steps

6-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(4-methoxyphenyl)-nicotinamide was prepared from 6-chloro-N-(4-methoxyphenyl)nicotinamide (Intermediate 2) and N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 8) using General Method B. LCMS: retention time 2.96 min, MH+ 402.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08252818B2
Source datasetuspto-grants-2012_08
ORD IDord-0c2752dae2834dd497848d9f232e6337
Source noteuspto-grants-2012_08