HRID889357

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)Nc1cccc(CNC(=O)c2ccc(Cl)nc2)c1

HCID21914545

未命名化合物

2 次

结构：Cc1ccc(C(=O)NN2NC=CS2)cc1B1OC(C)(C)C(C)(C)O1

HCID21914652

未命名化合物

2 次

PRODUCTS

生成物

结构：Cc1ccc(C(=O)NN2NC=CS2)cc1-c1ccc(C(=O)NCc2cccc(NS(C)(=O)=O)c2)cn1

HCID21914509

未命名化合物

PROCEDURE

实验过程

N-(3-Methylsulphonylaminobenzyl)-6-[2-methyl-5-(thiadiazol-2-ylcarbamoyl)-phenyl]-nicotinamide was prepared from 6-chloro-N-(3-methylsulphonylaminobenzyl)nicotinamide (Intermediate 4) and 4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiadiazol-2-yl)-benzamide (Intermediate 12) using General Method B. LCMS: retention time 2.80 min, MH+ 523. NMR: δH [2H6]-DMSO 9.35,(1H, t), 9.17,(2H, m), 8.38,(1H, d), 8.26,(1H, s), 8.09,(1H, d), 7.83,(1H, d), 7.52,(1H, d), 7.31,(1H, t), 7.22,(1H, s), 7.11,(2H, m), 4.52,(2H, d), 2.99,(3H, s), 2.46,(3H, s).