Triethylamine hydrochloride → HCID 53390437, compound

Participants

Reaction Conditions

Reaction Steps

Sodium azide (14 mg, 215 umol) and triethylamine hydrochloride (29 mg, 215 umol) were added to a solution of 4-{2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-3-fluoro-benzonitrile (20 mg, 43 umol; example 3) in DMF (0.5 ml). The solution was stirred at 120° C. for 14 h, poured onto ice water/1 N aqueous HCl solution 1/1 and extracted two times with iPrOAc. The combined extracts were washed with ice water/brine 1/1 and dried over Na2SO4. The solvent was removed under reduced pressure to give a solid which was crystallized from heptane/dichloromethane to obtain the title compound (13 mg, 26 umol; 59%) as off-white solid. MS: m/e=507.2 [M+H+].

Provenance & Evidence