HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-{2-[2-(4-Chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-{2-[2-(4-Chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-nicotinic acid methyl ester | HCID 67387180 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-{2-[2-(4-Chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-nicotinic acid | HCID 53390348 | — |
Reaction Steps
In analogy to the procedure described in example 2, 6-{2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-nicotinic acid methyl ester was hydrolysed using aqueous sodium hydroxide solution in MeOH to give the title compound as off-white solid. MS: m/e=466.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252826B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-346e4bead0624be08b0c6bd96a84beff |
| Source note | uspto-grants-2012_08 |