Sodium Hydroxide → HCID 53390349, compound

HRID 889383Notes

Reaction equation

HRID 889383 reaction equation
C[O:2][C:3](=[O:34])[C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH:12]([C:19]2[N:20]([C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[N:21]=[C:22]3[CH2:26][CH2:25][CH2:24][C:23]=23)[CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[Cl:33][C:30]1[CH:31]=[CH:32][C:27]([N:20]2[C:19]([CH:12]([CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]3)[CH2:11][S:10][C:7]3[CH:6]=[CH:5][C:4]([C:3]([OH:34])=[O:2])=[CH:9][CH:8]=3)=[C:23]3[CH2:24][CH2:25][CH2:26][C:22]3=[N:21]2)=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67387387HCID 67387387, compound

Product 1

HCID 53390349HCID 53390349, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to the procedure described in example 2, 4-{2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethylsulfanyl}-benzoic acid methyl ester was hydrolysed using aqueous sodium hydroxide solution in MeOH to give the title compound as off-white solid. MS: m/e=481.4 [M+H+].

Sources & evidence

ORD record
ord-172996f66ed14346b0478f60311819b0
Source dataset
uspto-grants-2012_08
Patent number
US08252826B2

Reaction notes

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