HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cycloheptanone → 2-Cyclohexyl-3-oxo-3-(2-oxo-cycloheptyl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cycloheptanone | HCID 10400 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | ethyl 3-(1H-benzotriazol-1-yl)-2-cyclohexyl-3-oxopropanoate | HCID 3722282 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Cyclohexyl-3-oxo-3-(2-oxo-cycloheptyl)-propionic acid ethyl ester | HCID 67387282 | — |
Reaction Steps
In analogy to the procedure described in example 1.2, 3-benzotriazol-1-yl-2-cyclohexyl-3-oxo-propionic acid ethyl ester (example 1.1) was treated with LDA and subsequently reacted with cycloheptanone (CAS Reg. No. 502-42-1) in THF to give the title compound as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252826B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-e5be39b2cdf44ea685b733e08a53a538 |
| Source note | uspto-grants-2012_08 |