HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-(4-Methoxybenzyl)propan-2-amine → 6-Chloro-8-(isopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-(4-Methoxybenzyl)propan-2-amine | HCID 4777650 | — |
| Reactant | 6-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 59313757 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Chloro-8-(isopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 86641383 | — |
Reaction Steps
10A was prepared from a mixture of 1F and N-(4-methoxybenzyl)propan-2-amine following the procedure employed for the preparation of 1G. HPLC: Rt=4.27 min. (YMC S5 ODS 4.6×50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min. gradient, monitored at 220 nm). MS (ES): m/z=356.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252795B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-9848dcddd7fe4bc587540a60d6af9428 |
| Source note | uspto-grants-2012_08 |