HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-methoxyphenyl)-N-methylmethanamine → 6-Chloro-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-methoxyphenyl)-N-methylmethanamine | HCID 485407 | — |
| Reactant | 6-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 59313757 | — |
| Product | 6-Chloro-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 86641386 | — |
Reaction Steps
16A was prepared from 1F and 1-(4-methoxyphenyl)-N-methylmethanamine following the procedure employed in the preparation of 1G. HPLC: Rt=3.12 min. (CHROMOLITH® column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 min. containing 0.1% TFA, 4 mL/min., monitoring at 220 nm). MS (ES): m/z=328.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252795B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-0851319784884de392b9a9893903f647 |
| Source note | uspto-grants-2012_08 |