HCID 3152375, compound → HCID 86641387, compound

HRID 889467Notes

Reaction equation

HRID 889467 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][NH:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:5][CH:4]=1.[Cl:19][C:20]1[CH:21]=[C:22](N(C2CC2)CC2C=CC(OC)=CC=2)[C:23]2[N:24]([C:26]([C:29]#[N:30])=[CH:27][N:28]=2)[N:25]=1>CO>[Cl:19][C:20]1[CH:21]=[C:22]([N:8]([CH2:7][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:18][CH:17]=2)[CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[C:23]2[N:24]([C:26]([C:29]#[N:30])=[CH:27][N:28]=2)[N:25]=1

Participants

4

Reactant 2

HCID 3152375HCID 3152375, compoundHCID 593137576-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile

Product 1

HCID 86641387HCID 86641387, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

17A was prepared from 1F and N-(4-methoxybenzyl)-2-(4-morpholinyl)ethanamine following the procedure employed in the preparation of 1G. HPLC: Rt=2.95 min. (YMC S5 ODS 4.6×50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min. gradient, monitored at 220 nm). MS (ES): m/z=427.1 [M+H]+.

Sources & evidence

ORD record
ord-b0ad71e89ee841db9c8d7959c417439a
Source dataset
uspto-grants-2012_08
Patent number
US08252795B2

Reaction notes

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