HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-(4-methoxybenzylamino)benzoate → tert-Butyl 3-((6-chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-(4-methoxybenzylamino)benzoate | HCID 59313743 | — |
| Reactant | 6-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 59313757 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 3-((6-chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)benzoate | HCID 59314053 | — |
Reaction Steps
253B was prepared from 253A and a mixture of 1F following the procedure as described in 1G. HPLC: Rt=4.99 min. (PHENOMENEX® Luna C18 4.6×30 mm 3 u, A10-90% aqueous methanol containing 0.1% TFA in 2 min; 4 mL/min flow). MS (ES): m/z=490.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252795B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-08761f56f2d349d190a6fd7919f2ed0a |
| Source note | uspto-grants-2012_08 |