反应详情

Ethyl {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetate (20.2 g, 44.8 mmol) was suspended in ethanol (450 ml) and treated with 2N sodium hydroxide (150 ml). The mixture was heated under reflux for 1 hour then cooled, and concentrated in vacuo to ˜200 ml, then acidified with 2N hydrochloric acid. The white solid was collected by filtration, washed with water (500 ml) and dried in a vacuum oven to yield the title compound as a cream solid (18.45 g, 43.6 mmol).

1. temperatureThe mixture was heated
2. temperatureunder reflux for 1 hour
3. temperaturethen cooled
4. concentrationconcentrated in vacuo to ˜200 ml
5. filtrationThe white solid was collected by filtration
6. washwashed with water (500 ml)
7. customdried in a vacuum oven