Triethylsilane → HCID 58399557, compound

Participants

Reaction Steps

To a stirred solution of ethyl {4-[4,9-bis(ethyloxy)-1-hydroxy-3-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-3,5-difluorophenyl}acetate (0.240 g, 0.495 mmol) in TFA (3 ml) at 0° C. was added triethylsilane (0.118 ml, 0.742 mmol) drop wise. The bright red solution turned light yellow on addition. The mixture was evaporated then purified by MDAP. The fractions were evaporated to give a yellow solid (0.049 g, 0.10 mmol) LC/MS: Rt=3.62, [MH]+ 470.

Provenance & Evidence