Ethanol → Ethyl 2-(4-amino-2-fluorophenyl)acetate
반응식
S(Cl)(Cl)=O.[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[C:8]([F:16])[CH:7]=1.[CH2:17](O)[CH3:18]>>[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([O:15][CH2:17][CH3:18])=[O:14])=[C:8]([F:16])[CH:7]=1참가 물질
반응 조건
- 온도
- 40 °C
실험 절차
Thionyl chloride (986 mL, 8.51 mol) was added dropwise to a stirred suspension of 2-(4-amino-2-fluorophenyl)acetic acid (960 g, 5.68 mol) in ethanol (10 L) at 0° C. under a nitrogen atmosphere. The reaction mixture was then heated to 40° C. for 48 hours, with the reaction progress monitored by 1H-nmr spectroscopy. The reaction mixture was evaporated to dryness and the residue redissolved in a mixture of dichloromethane (8 L) and saturated sodium hydrogen carbonate solution (5 L). Further sodium hydrogen carbonate solution was added (˜8 L) until the aqueous phase was basic. The layers were separated and the organic phase washed with saturated sodium hydrogen carbonate solution (4 L), dried over magnesium sulphate and the solvent removed under reduced pressure gave the desired product, ethyl (4-amino-2-fluorophenyl)acetate, as an orange oil (1042 g, 93% yield), that may crystallise upon standing.
후처리
- customThe reaction mixture was evaporated to dryness
- dissolutionthe residue redissolved in a mixture of dichloromethane (8 L) and saturated sodium hydrogen carbonate solution (5 L)
- additionFurther sodium hydrogen carbonate solution was added (˜8 L) until the aqueous phase
- customThe layers were separated
- washthe organic phase washed with saturated sodium hydrogen carbonate solution (4 L)
- dry with materialdried over magnesium sulphate
- customthe solvent removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-a9636558b1e14f57895b543495d3e5cd
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08252833B2
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