huagongshe.com
HRID889524

反应详情

EQUATION

反应方程式

HRID 889524 的结构方程式

REACTANTS

反应物

2
结构：CO
HCID887

Methanol

CH4O

结构：CCCCc1nc(Cl)c(C(=O)OC(C)OC(=O)OCCC(C)[C@@H](O[N+](=O)[O-])[C@@H](C)O[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1
HCID86647020

未命名化合物

PRODUCTS

生成物

1
结构：CCCCc1nc(Cl)c(C(=O)OC(C)OC(=O)OCCC(C)[C@@H](O[N+](=O)[O-])[C@@H](C)O[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
HCID178441695

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
70 °C

PROCEDURE

实验过程

1-[({[(4R,5R)-3-methyl-4,5-bis(nitrooxy)hexyl]oxy}carbonyl)oxy]ethyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate (1.08 g, 1.09 mmol) was dissolved in CH2Cl2 (3 mL) and MeOH was added (17 mL). The solution was heated in a microwave apparatus (70° C., 40 minutes). The solution was then concentrated and the residue was purified by flash chromatography (Biotage SP1, SNAP 100 g column, CH2Cl2/MeOH 98:2) affording the title compound.

WORKUP

后处理

  1. concentrationThe solution was then concentrated
  2. customthe residue was purified by flash chromatography (Biotage SP1, SNAP 100 g column, CH2Cl2/MeOH 98:2)