Hydrochloric Acid → HCID 67970680, compound

Participants

Reaction Steps

Dissolve 5-[(tert-butoxycarbonylaminomethyl)-2-chloro-N-(1H-imidazol-2-yl)benzamide (640 mg, 1.82 mmol, 1.0 equiv) in hydrochloric acid (4 M in dioxane, 4.56 mL, 18.24 mmol, 10.0 equiv) and stir at room temperature for 1 h. Pour the reaction mixture into vigorously swirling EtOAc (50 mL), isolate the resulting white precipitate by filtration, wash with EtOAc (25 mL), and dry in a 40° C. vacuum oven overnight to provide the title compound as a white solid (590 mg, 100%). 1H NMR (D2O, 400 MHz) δ 7.53 (d, 1H, J=2.0 Hz), 7.48 (d, 1H, J=8.3 Hz), 7.46 (dd, 1H, J=8.3, 2.0 Hz), 7.04 (s, 2H), 4.05 (s, 2H).

Provenance & Evidence