HRID889577

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CS(=O)(=O)O.Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1

HCID123596

Imatinib mesylate

C30H35N7O4S

反应SMILES：CN1CCN(Cc2ccc(C(=O)Cl)cc2)CC1.Cl.Cl

HCID20227042

4-[(4-Methylpiperazin-1-yl)methyl]benzoyl chloride--hydrogen chloride (1/2)

C13H19Cl3N2O

反应SMILES：Cc1ccc(N)cc1-c1cnc(N)nc1-c1cccnc1

HCID86662501

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1.Cl

HCID10437009

未命名化合物

PROCEDURE

实验过程

In another embodiment, the invention encompasses processes for preparing imatinib mesylate comprising: (a) condensing N-(2-methyl-5-aminophenyl-4-(3-pyridyl)-2-pyrimidine-amine and 4-(4-methylpiperazin-1-yl-methyl)benzoyl chloride dihydrochloride in the presence of a solvent to obtain imatinib hydrochloride; (b) combining the imatinib hydrochloride with a base to obtain imatinib base; and (c) combining the imatinib base with methanesulfonic acid to obtain imatinib mesylate, wherein the solvent is not an organic solvent.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6a0693f0d9be4187b148940300a1632f
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08252926B2
来源说明: uspto-grants-2012_08

反应SMILES

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([CH2:30][N:31]3[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]3)=[CH:28][CH:29]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.CS(O)(=O)=O.CC1C=CC(N)=CC=1C1C(C2C=NC=CC=2)=NC(N)=NC=1.Cl.Cl.CN1CCN(CC2C=CC(C([Cl:80])=O)=CC=2)CC1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)=[CH:26][CH:25]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[ClH:80]