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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 889632Generated: October 26, 2026

Trifluoromethanesulfonic acid 1-butyl-3-chloro-2-oxo-1,2-dihydropyridin-4-yl ester → Trifluoromethanesulfonic acid 3-chloro-1-cyclopropylmethyl-2-oxo-1,2-dihydro-pyridin-4-yl ester

https://huagongshe.com/reaction/889632

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoromethanesulfonic acid 1-butyl-3-chloro-2-oxo-1,2-dihydropyridin-4-yl esterHCID 25221428—
Reactant3-Chloro-1-(cyclopropylmethyl)-4-hydroxypyridin-2(1H)-oneHCID 67310180—
ProductTrifluoromethanesulfonic acid 3-chloro-1-cyclopropylmethyl-2-oxo-1,2-dihydro-pyridin-4-yl esterHCID 58505315—

Reaction Steps

Intermediate D5 was prepared following the same procedure used for the synthesis of intermediate D4, but using intermediate 3-chloro-1-cyclopropylmethyl-4-hydroxy-1H-pyridin-2-one as starting material.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08252937B2
Source datasetuspto-grants-2012_08
ORD IDord-296939a35abb4635b6765a55ab00e4b1
Source noteuspto-grants-2012_08