反应详情

N-Iodosuccinimide (2.64 g, 11.74 mmol) was added to a solution of intermediate D1 (3.0 g, 11.74 mmol) in acetic acid (40 ml). The reaction mixture was stirred at room temperature for 1 hour, after which it was concentrated in vacuo. The residue was purified by column chromatography (silica gel; DCM as eluent) and finally recrystallized from diethyl ether to yield intermediate D6 (4.12 g, 92%) as a solid.

1. concentrationafter which it was concentrated in vacuo
2. customThe residue was purified by column chromatography (silica gel; DCM as eluent)
3. customfinally recrystallized from diethyl ether