Hydrochloric Acid → Tigecycline Hydrochloride

Participants

Reaction Steps

A solution of Tigecycline was prepared by mixing 500 mg of a solid Tigecycline sample with 10 ml acetone. Within about 5 minutes a precipitate appeared and the suspension was further stirred for 1.75 h. 143 μl (1.0 mol equivalent) 5N hydrochloric acid were added to the suspension and stirring was continued for 5 hours. Finally the solid was filtered off, washed with acetone and dried at room temperature under vacuum to obtain 440 mg (97% yield) of crystalline form A of Tigecycline hydrochloride (98.73% purity by HPLC).

Provenance & Evidence