Diisopropylethylamine → HCID 57665994, compound

Participants

Reaction Conditions

Reaction Steps

4-Methyl-2-[4′-trifluoromethyl-5-(6-trifluoromethyl-piperidin-2-yl)-biphenyl-3-yl]-pentanoic acid ethyl ester 7b (37 mg, 0.072 mmol), 4-trifluoromethylbenzyl bromide (86 mg, 0.36 mmol), DIEA (125 μl, 0.72), and tetrabutylammonium iodide (TBAI)(10 mg, 0.096 mmol) were combined and heated under microwave conditions to 150° C. After several additions of the starting materials and ˜90 minutes under microwave, ˜50% product was formed. The reaction was diluted with EtOAc, washed with brine, sat. NaHCO3, and brine, dried over magnesium sulfate and filtered. Purification by silica gel chromatography gave the product as yellow oil. (25 mg, 52%) (M+H) 73.65, Found 674.4

Provenance & Evidence