Diisopropylethylamine → HCID 57666072, compound

Participants

Reaction Steps

To a solution of compound 33b 4-Methyl-2-(5-piperidin-3-yl-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid ethyl ester (60.8 mg, 0.136 mmol) in CH3CN (5 ml) was added 4-Trifluoromethoxybenzylbromide) (33 μl, 0.20 mmol) and diisopropylethylamine (47 μl, 0.27 mmol). The reaction was microwaved at 130° C. for 10 minutes, then diluted with EtOAc and washed with brine, sat. NaHCO3, and brine, dried and filtered. Purification by silica gel chromatography (Isco) gave the desired product as a clear oil, (69.7 mg, 83%). Calcd for C34H37F6NO3 (M+H) 621.65, Found 622.3

Provenance & Evidence