Diisopropylethylamine → HCID 57665949, compound

Participants

Reaction Steps

To a solution of compound 33b, 4-Methyl-2-(5-piperidin-3-yl-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid ethyl ester (85 mg, 0.19 mmol) in CH3CN (5 ml) was added 1-Bromomethyl-3,5-bis-trifluoromethyl-benzene (88.0 mg, 0.29 mmol), and diisopropylethylamine (66 μl, 0.38 mmol). The reaction was microwaved at 130° C. for 10 minutes. The reaction was diluted with EtOAc and washed with brine, sat. NaHCO3, and brine, dried and filtered. Purification by silica gel chromatography (Isco) gave the desired product, (109 mg, 85%). Calcd for C35H36F9NO2 (M+H) 673.65, Found 675.4

Provenance & Evidence