Sodium Hydroxide → HCID 25269422, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-4-methyl-2-[5-(2-phenethyl-piperidin-1-yl)-4′-trifluoromethyl-biphenyl-3-yl]-pentanoic acid methyl ester (14 mg, 0.03 mmol) in MeOH (2 mL) was added 1N NaOH (0.100 mL) and heated to 60° C. for 2 h. The reaction was concentrated in vacuo to remove MeOH. The thick liquid was acidified to pH=2 by 2N HCl. The resulting acidic solution was extracted with EtOAc. The organic fraction was dried (MgSO4) and concentrated in vacuo. The crude mixture was purified by Gilson reverse phase column chromatography to obtain (R)-4-methyl-2-[5-(2-phenethyl-piperidin-1-yl)-4′-trifluoromethyl-biphenyl-3-yl]-pentanoic acid. 1H-NMR (MeOD-d4): δ 0.84 (m, 6H), 1.40 (m, 1H), 1.60-1.76 (m, 5H), 1.93 (m, 4H), 2.28-2.41 (m, 2H), 2.59 (m, 1H), 3.56-3.73 (m, 3H), 3.78 (q, 1H), 6.85 (s, 1H), 6.87 (s, 1H), 6.98 (m, 1H), 7.04 (m, 2H), 7.47-7.57 (m, 2H), 7.71 (s, 5H); Calcd for C32H36F3NO2 (M+H) 524.63, Found 524.3

Provenance & Evidence