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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 88979Generated: October 28, 2026

Methanol → 4-[1-(2-Amino-ethyl)-4-(3-chloro-4-fluoro-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/88979

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantNickel DichlorideHCID 24385—
Reactant4-[4-(3-Chloro-4-fluoro-phenyl)-1-cyanomethyl-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl esterHCID 67265534—
Product4-[1-(2-Amino-ethyl)-4-(3-chloro-4-fluoro-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl esterHCID 67265114—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-5c348e47cd5f4552b596f1509d808c40
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)