Propylene Oxide → HCID 9834706, compound

Participants

Reaction Steps

In Example 2, 16 mg of tri-tert-ethoxy aluminum was used in place of anhydrous aluminum chloride, and the color of the catalyst solution changed from brown to slightly greenish brown by the addition of tri-tert-ethoxy aluminum. Then 4-phenoxyphenol and propylene oxide were added to the slightly greenish brown catalyst solution to achieve the reaction in the same manner as described in Example 2. Thus (S)-(+)-1-(4-phenoxyphenoxy)-2-propanol was obtained in 83% yield and the optical purity was 90% e.e.

Provenance & Evidence