Propylene Oxide → HCID 9834706, compound

Participants

Reaction Steps

In Example 2, the amount of (R,R)-(−)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino cobalt (III) 4-phenoxyphenolate used was changed to 41 mg, and 15 mg of tetraisopropoxy titanium was used in place of anhydrous aluminum chloride, and the color of the catalyst solution changed from brown to slightly greenish brown by the addition of tetraisopropoxy titanium. Then 4-phenoxyphenol and propylene oxide were added to the slightly greenish brown catalyst solution to achieve the reaction in the same manner as described in Example 2. Thus (S)-(+)-1-(4-phenoxyphenoxy)-2-propanol was obtained in 77% yield and the optical purity was 94% e.e.

Provenance & Evidence