反应详情

A mixture of 4,4′-dimethoxybenzil (13.6 g, 50 mmol) and 6.06 g of thiosemicarbazide (66.5 mmol) in 50 mL of glacial acetic acid were stirred at room temperature then refluxed overnight. The cooled reaction mixture was diluted with 150 mL of water and filtered. The solids were washed with water and dried. The crude product was heated with 55 mL of ethyl acetate, cooled, filtered and dried to give 10.1 g of 5,6-bis-(4-methoxyphenyl)-1,2,4-triazin-3-thione, mp 228–232° C.

1. temperaturethen refluxed overnight
2. customThe cooled reaction mixture
3. filtrationfiltered
4. washThe solids were washed with water
5. customdried
6. temperatureThe crude product was heated with 55 mL of ethyl acetate
7. temperaturecooled
8. filtrationfiltered
9. customdried