2-Methylphenyl boronic acid → HCID 22248671, compound

Participants

Reaction Steps

In a similar manner to Reference Example 11, 4-[3,5-bis(trifluoromethyl)benzyl]-6-chloro-8-(methylthio)-5-oxo-2,3,4,5-tetrahydropyrimido[5,4-f][1,4]oxazepine (Compound of Reference Example 10; 2.36 g) was reacted with 2-methylphenylboronic acid (816 mg) to obtain 4-[3,5-bis(trifluoromethyl)benzyl]-6-(2-methylphenyl)-8-(methylthio)-5-oxo-2,3,4,5-tetrahydropyrimido[5,4-f][1,4]oxazepine (2.13 g, 81%).

Provenance & Evidence