HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isophthaloyl chloride → 1-N,3-N-bis[(4-fluorophenyl)methyl]benzene-1,3-dicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isophthaloyl chloride | HCID 7451 | — |
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-N,3-N-bis[(4-fluorophenyl)methyl]benzene-1,3-dicarboxamide | HCID 1294467 | 27.4% |
Reaction Steps
4-Fluoro-benzylamine (1.25 g) is added to isophthaloyl dichloride (1.015 g) in toluene (100 mL). The reaction mixture is stirred at room temperature for 4 days. The product is filtered off and washed with toluene. Recrystallization from methanol gives the product (0.52 g), mp 190–191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06995151B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-f9b4ee8cf1264e25a7d3941be31c59e5 |
| Source note | uspto-grants-2006_02 |