9-(2-Chloroethyl)-9H-purin-6-amine → HCID 69641888, compound

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Reaction Steps

0.6 g (3 mmol) 9-(chloroethyl)-6-amino-9H-purine (Chemistry of Heterocyclic Compounds, 1996, 32, 333–337) was dissolved in 10 ml n-butanol and treated with 0.684 g (9 mmol) of N-methylaminoethanol at 110° C. for 18 h. The solvent was evaporated under reduced pressure and the crude mixture purified by flash chromatography on silica gel with a gradient of 0 to 25% methanol in dichloromethane to yield 0.68 g (94%) of a light orange solid. MS (ISP): 237.3 (MH+).

Provenance & Evidence