HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R,4R)-pyrrolidine-3,4-diol → (3r,4r)-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-(3,4-dihydroxy-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R,4R)-pyrrolidine-3,4-diol | HCID 11499204 | — |
| Reactant | Lithium 7-chlorothieno[3,2-b]pyridine-2-carboxylate | HCID 23677819 | — |
| Product | (3r,4r)-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-(3,4-dihydroxy-pyrrolidin-1-yl)-methanone | HCID 23595107 | — |
Reaction Steps
The title compound was prepared from lithium 7-chloro-thieno[3,2-b]pyridine-2-carboxylate and (3R,4R)-pyrrolidine-3,4-diol by a procedure analogous to Example 1C. MS: 299.3/301.3 (MH+); HPLC Rf: 3.091 min.; HPLC purity: 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06995171B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-bd3c09a085ca4c718ec0b317f9362cc1 |
| Source note | uspto-grants-2006_02 |