2-methyl-1H-indol-5-ol → HCID 10137974, compound

HRID 889884Notes

Reaction equation

HRID 889884 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][C@@H:16]([O:18][CH3:19])[C@H:15]([O:20][CH3:21])[CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:22][C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([OH:32])=[CH:27][CH:26]=2>>[CH3:21][O:20][C@H:15]1[C@H:16]([O:18][CH3:19])[CH2:17][N:13]([C:11]([C:9]2[S:10][C:3]3[C:4](=[N:5][CH:6]=[CH:7][C:2]=3[O:32][C:28]3[CH:29]=[C:30]4[C:25](=[CH:26][CH:27]=3)[NH:24][C:23]([CH3:22])=[CH:31]4)[CH:8]=2)=[O:12])[CH2:14]1

Participants

3

Reactant 2

HCID 833362-methyl-1H-indol-5-olHCID 23595108HCID 23595108, compound

Product 1

HCID 10137974HCID 10137974, compound

Procedure

The title compound was prepared from (3R,4R)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3,4-dimethoxy-pyrrolidin-1-yl)-methanone and 2-methyl-1H-indol-5-ol by a procedure analogous to Example 1F. MS 438.3 (MH+); HPLC Rf: 5.554 min.; HPLC purity: 97%.

Sources & evidence

ORD record
ord-0bad81eb08804d54bfddb058cb084105
Source dataset
uspto-grants-2006_02
Patent number
US06995171B2

Reaction notes

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