2-methyl-1H-indol-5-ol → HCID 10201449, compound

HRID 889885Notes

Reaction equation

HRID 889885 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][CH2:15][C@@H:14]3[CH2:18][OH:19])=[O:12])[S:10][C:3]=12.[CH3:20][C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([OH:30])=[CH:25][CH:24]=2>>[OH:19][CH2:18][C@H:14]1[CH2:15][CH2:16][CH2:17][N:13]1[C:11]([C:9]1[S:10][C:3]2[C:4](=[N:5][CH:6]=[CH:7][C:2]=2[O:30][C:26]2[CH:27]=[C:28]3[C:23](=[CH:24][CH:25]=2)[NH:22][C:21]([CH3:20])=[CH:29]3)[CH:8]=1)=[O:12]

Participants

3

Reactant 2

HCID 833362-methyl-1H-indol-5-olHCID 20745991HCID 20745991, compound

Product 1

HCID 10201449HCID 10201449, compound

Procedure

The title compound was prepared from (R)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(2-hydroxymethyl-pyrrolidin-1-yl)-methanone and 2-methyl-1H-indol-5-ol by a procedure analogous to Example 1F. MS: 408.3 (MH+); HPLC Rf: 5.146 min.; HPLC purity: 98%.

Sources & evidence

ORD record
ord-fe954860ca304518a5c1d7c8a3170586
Source dataset
uspto-grants-2006_02
Patent number
US06995171B2

Reaction notes

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