Methyl iodide → HCID 10137860, compound

HRID 889888Notes

Reaction equation

[CH3:1][O:2][CH2:3][C@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]([C:11]1[S:19][C:18]2[C:13](=[N:14][CH:15]=[CH:16][C:17]=2[O:20][C:21]2[CH:22]=[C:23]3[C:27](=[CH:28][CH:29]=2)[NH:26][C:25]([CH3:30])=[CH:24]3)[CH:12]=1)=[O:10].[CH3:31]I>>[CH3:31][N:26]1[C:27]2[C:23](=[CH:22][C:21]([O:20][C:17]3[CH:16]=[CH:15][N:14]=[C:13]4[CH:12]=[C:11]([C:9]([N:5]5[CH2:6][CH2:7][CH2:8][C@@H:4]5[CH2:3][O:2][CH3:1])=[O:10])[S:19][C:18]=34)=[CH:29][CH:28]=2)[CH:24]=[C:25]1[CH3:30]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 10159192HCID 10159192, compound

Product 1

HCID 10137860HCID 10137860, compound

Procedure

The title compound was prepared by the method described for Example 10, using (2R)-(2-methoxymethyl-pyrrolidin-1-yl)-[7-(2-methyl-1H-indol-5-yloxy)-thieno[3,2-b]pyridin-2-yl]-methanone and methyl iodide. MS: 436 (MH+); HPLC Rf: 6.33 min; HPLC purity: 96%.

Sources & evidence

ORD record: ord-6d54f1d02c4d4fd492323ea9910e0e38
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995171B2

Reaction notes

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