2-[2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-thiazol-4-yl]-propan-2-ol → 2-{2-[7-(1-Methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-thieno[3,2-b]pyridin-2-yl]-thiazol-4-yl}-propan-2-ol

HRID 889895ノート

反応式

HRID 889895 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[S:12][CH:13]=[C:14]([C:16]([OH:19])([CH3:18])[CH3:17])[N:15]=3)[S:10][C:3]=12.[CH3:20][N:21]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][C:23]([OH:30])=[N:22]1>>[CH3:20][N:21]1[C:25]([C:26]([F:27])([F:28])[F:29])=[CH:24][C:23]([O:30][C:2]2[CH:7]=[CH:6][N:5]=[C:4]3[CH:8]=[C:9]([C:11]4[S:12][CH:13]=[C:14]([C:16]([OH:19])([CH3:18])[CH3:17])[N:15]=4)[S:10][C:3]=23)=[N:22]1

参加物

3

反応物 2

HCID 221436652-[2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-thiazol-4-yl]-propan-2-olHCID 178481944HCID 178481944、化合物

生成物 1

HCID 102252532-{2-[7-(1-Methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-thieno[3,2-b]pyridin-2-yl]-thiazol-4-yl}-propan-2-ol収率 8%

実験手順

The title compound (11 mg, 8%) was prepared from 2-[2-(7-chloro-thieno[3,2-b]pyridin-2-yl)-thiazol-4-yl]-propan-2-ol and 1-methyl-5-trifluoromethyl-1H-pyrazol-3-ol by a procedure analogous to Example 16. C18H15F3N4O2S2: APCI m/z 441.3 (pos.); 1H NMR (CD3OD): δ 8.53 (d, 1H, J=5.6 Hz), 7.91 (s, 1H), 7.48 (s, 1H), 7.07 (d, 1H, J=5.6 Hz), 6.68 (s, 1H), 3.98 (s, 3H), 1.61 (s, 6H) ppm.

出典と根拠

ORDレコード
ord-c693d898bb524cf38679f84c99f5051a
出典データセット
uspto-grants-2006_02
特許番号
US06995171B2

反応ノート

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