2-methyl-1H-indol-5-ol → {4-Methyl-2-[7-(2-methyl-1H-indol-5-yloxy)-thieno[3,2-b]pyridin-2-yl]-thiazol-5-yl}-(4-methyl-piperazin-1-yl)-methanone

Participants

Reaction Steps

The title compound (77 mg, 51%) was prepared from [2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-4-methyl-thiazol-5-yl]-(4-methyl-piperazin-1-yl)-methanone and 2-methyl-1H-indol-5-ol by a procedure analogous to Example 16 as a tan colored hydrochloride salt. C26H25N5O2S2: APCI m/z 504.3 (pos.); 1H NMR (CD3OD): δ 8.46 (d, 1H, J=5.4 Hz), 7.99 (s, 1H), 7.35 (d, 1H, J=8.3 Hz), 7.26 (s, 1H), 6.87 (d, 1H, J=8.3 Hz), 6.67 (d, 1H, J=5.4 Hz), 6.17 (s, 1H), 3.8–3.0 (bm, 8H), 2.95 (s, 3H), 2.49 (s, 3H), 2.43 (s, 3H) ppm.

Provenance & Evidence