5-Hydroxy-2-methyl-1h-indole-3-carbonitrile → HCID 10165314, compound

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Reaction Steps

The title compound (61 mg, 41%) was prepared from [2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-4-methyl-thiazol-5-yl]-(4-methyl-piperazin-1-yl)-methanone and 5-Hydroxy-2-methyl-1 H-indole-3-carbonitrile by a procedure analogous to Example 16 using and in a 41% yield. C27H25N6O2S2: APCI m/z 529.4 (pos.); 1H NMR (CD3OD): δ 8.72 (d, 1H, J=6.6 Hz), 8.17 (s, 1H), 7.60 (d, 1H, J=8.7 Hz), 7.58 (s, 1H), 7.23 (d, 1H, J=8.7 Hz), 7.07 (d, 1H, J=6.6 Hz), 3.65–3.15 (bm, 8H), 2.96 (s, 3H), 2.63 (s, 3H), 2.52 (s, 3H) ppm.

Provenance & Evidence