Morpholine → HCID 22250082, compound

HRID 889904Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[S:12][C:13]([C:17](Cl)=[O:18])=[C:14]([CH3:16])[N:15]=3)[S:10][C:3]=12.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[S:12][C:13]([C:17]([N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)=[O:18])=[C:14]([CH3:16])[N:15]=3)[S:10][C:3]=12

Participants

Reactant 2

HCID 8083Morpholine

HCID 22250084HCID 22250084, compound

Product 1

HCID 22250082HCID 22250082, compoundYield 82%

Procedure

[2-(7-Chloro-thieno[3,2-b]pyridin-2-yl) -4-methyl-thiazol-5-yl]-morpholin-4-yl-methanone (532 mg, 82%) was prepared from 2-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-4-methyl-thiazole-5-carbonyl chloride and morpholine in a procedure analogous to Example 20. C16H14ClN3O2S2: APCI m/z 380.0/382.1 (pos.).

Sources & evidence

ORD record: ord-b5ed3b757c7c402096e4e906d89e19a7
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995171B2

Reaction notes

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