HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 889983Generated: October 29, 2026
Ammonium Chloride → 4-(Morpholinomethyl)aniline
https://huagongshe.com/reaction/889983
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-(4-Nitrobenzyl)morpholine | HCID 783183 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(Morpholinomethyl)aniline | HCID 776851 | — |
Reaction Steps
A mixture of 4-[(4-nitrophenyl)methyl]morpholine (220 mg, 1.0 mmol, Step A), iron powder (279 mg, 5.0 mmol) and NH4Cl (39 mg, 0.7 mmol) in EtOH (3 mL) and H2O (3 mL) was stirred for 4 h at 80° C. Filtration and concentration gave the crude 4-(morpholin-4-ylmethyl)-phenylamine, which was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06995162B2 |
|---|
| Source dataset | uspto-grants-2006_02 |
|---|
| ORD ID | ord-50d94015a6924827bf288d2197746e7e |
|---|
| Source note | uspto-grants-2006_02 |
|---|
