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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 890002Generated: October 29, 2026

HCID 22249265, compound → HCID 22249256, compound

https://huagongshe.com/reaction/890002

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 22249265HCID 22249265—
CatalystNickelHCID 935—
SolventEthanolHCID 702—
ProductHCID 22249256HCID 22249256—

Reaction Steps

A mixture of N-[4-(isopropyl)phenyl]{2-methylthio-4-[(4-pyridylmethyl)amino]pyrimidin-5-yl}carboxamide (50 mg, 0.13 mmol, Step B) and Raney-Ni in EtOH (10 mL) was heated at reflux for 2 h. The resulting mixture was filtered, and the filtrate was concentrated to give the titled compound. MS (ES+): 348 (M+H)+; (ES−): 346 (M−H)−. Calc'd C20H21N5O—347.42.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06995162B2
Source datasetuspto-grants-2006_02
ORD IDord-bf68a718eca34f4e8499ec1d13088116
Source noteuspto-grants-2006_02