Hydrochloric Acid → HCID 22250306, compound

Participants

Reaction Steps

A stirred solution of 4-[3-(phenylsulfonyl)-1H-indol-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 1.10 mmol) in dioxane is treated with 4N HCl in dioxane (4.5 mL, 18 mmol), stirred for 5 h at ambient temperature and concentrated in vacuo. Crystallization of the resultant solid residue from ethanol:ether affords the title compound as a white solid, 351 mg (82% yield), mp>250° C., identified by HNMR and mass spectral analyses.

Provenance & Evidence